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In The News Internal Medicine Outpatients with Inflammatory Bowel Disease at Increased Risk for VTE
In The News Internal Medicine Outpatients with Inflammatory Bowel Disease at Increased Risk for VTE
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In The News Internal Medicine Outpatients with Inflammatory Bowel Disease at Increased Risk for VTE
| Outpatients with Inflammatory Bowel Disease at Increased Risk for VTE |
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| Posted by Dr. Johanne Perez M.D |
| Friday, 12 February 2010 16:29 |
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Physician's First Watch for February 9, 2010 David G. Fairchild, MD, MPH, Editor-in-Chief Nonhospitalized patients with inflammatory bowel disease have a nearly 16-fold increased risk for venous thromboembolism during acute flare-ups, according to a Lancet study released online.
Risks were increased at all stages of disease, including remission. Commentators caution against a drug-based approach to prophylaxis in these patients until further studies are done. They recommend, instead, educating patients on the symptoms of VTE and the use of support stockings.
Lancet article (Free abstract; full text requires subscription) Lancet comment (Subscription required)
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Using a U.K. general practice database, researchers identified some 14,000 bowel disease patients with a recent prescription for corticosteroids and some 72,000 controls without inflammatory bowel disease matched for age, sex, and provider. In the 4 months after patients received the prescription (corresponding to a likely disease flare-up), the relative risk for VTE outside the hospital setting was roughly 16 (absolute risk, 6.4 per 1000 person-years).
